Table 7.
Antiviral activity of inhibitors against highly DRV-resistant HIV-1 variants.
| Mean IC50 in nM ± SD (fold-change) | |||||
|---|---|---|---|---|---|
| LPV | 1 | 62 | 63 | 2 (GRL-142) | |
| cHIVnl4-3WT | 13 ± 2 | 3.2 | 48.9 | 37.7 | 0.017 |
| HIVDRVRP20 | >1000 (>77) | 525.8 (164) | 219.3 (4) | 71.2 (2) | 0.0024 |
| HIVDRVRP30 | >1000 (>77) | 601 (>187) | 946.4 (19) | 532.3 (14) | 0.14 |
| HIVDRVRP51 | >1000 (>77) | 5429.7 (>1000) | >1000 | >1000 | 1.3 |
Numbers in parentheses represent fold changes in IC50s for each isolate compared to the IC50s for wild-type cHIVNL4-3WT. All assays were conducted in triplicate.