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. 2024 Mar 15;13:RP92200. doi: 10.7554/eLife.92200

Figure 6. Inter-species anatomical sex congruence and gene expression shows modest correlation across homologous brain regions.

Correlation between similarity in volumetric sex differences and similarity in transcriptional profile using all homologous genes across all homologous regions is modest (A).There was a stronger correlation across cortical (green) compared to non-cortical (purple) regions (B). Robust correlation used to assess correlation between anatomical sex effect similarity and transcriptional similarity yeild r and p values.

Figure 6.

Figure 6—figure supplement 1. Similarity matrix for cross-species homologous gene expression.

Figure 6—figure supplement 1.

The matrix displays the correlation between 56 homologous human (x-axis) and mouse (y-axis) brain regions based on the expression of 2835 homologous genes. Hierarchical clustering was used to order the rows and columns using the R function pheatmap; n for humans = 516F/454M, n for mice = 213F/216M. Pearson correlation was used to generate the similarity matrix between all pairs of human and mouse regions; colors denote strenght of pearson correlation coefficient (warm for positive r value, cool for negative r value).
Figure 6—figure supplement 2. Recomputing inter-species anatomical sex congruence and gene expression exlcuding BNST shows similar correlation to analysis including all homologous brain regions.

Figure 6—figure supplement 2.

Correlation between similarity in volumetric sex differences and similarity in transcriptional profile using all homologous genes across but exlcuding the BNST from homologous regions list (A). There was a stronger correlation across cortical (green) compared to non-cortical (purple) regions (B). Robust correlation used to assess correlation between anatomical sex effect similarity and transcriptional similarity yeild r and p values.