Table 2.

Genome-wide significant variants (P-value < 5e−08) in the meta-analysis results of acute pancreatitis GWAS in UK Biobank and MVP.

Variants	Effect allele	Other allele	EAF	N	Effect size	S.E	P-value	Direction	Nearest Gene	Distance to nearest gene (bp)	Function	CADD
rs10901252	C	G	0.09	1,112,238	0.14	0.02	1.52E−12	+  +	ABO:RP11-430N14.4	0:0	ncRNA exonic	0.20
rs113812546	A	C	0.02	1,112,238	0.22	0.04	2.39E−08	+  +	WNT2	4494	Intergenic	0.41
rs117046683	A	C	0.55	1,112,238	0.07	0.01	1.20E−08	+  +	PRSS1	2664	Intergenic	0.40
rs142703147	A	C	0.01	1,112,238	0.48	0.05	2.02E−18	+  +	SPINK1	3931	Intergenic	14.58
rs28929474	T	C	0.02	1,112,238	0.29	0.04	4.04E−11	+  +	SERPINA1	0	Exonic	20.20
rs35471107	C	G	0.56	1,112,238	0.08	0.01	8.22E−09	+  +	SST	37,465	Intergenic	0.64
rs74355737	A	C	0.99	170,754	− 0.59	0.10	2.25E−08	?-	ZNF618	0	Intronic	0.83
rs77725792	A	G	0.07	1,112,238	0.13	0.02	2.00E−08	+  +	ABCG5	0	Intronic	0.49
rs9677610	A	G	0.45	1,112,238	− 0.07	0.01	1.23E−08	–	AC113618.1	7433	Intergenic	1.89

EAF Effect allele frequency, S.E Standard Error, bp base pairs, ncRNA non-coding RNA, CADD Combined annotation dependent depletion.