Table 5.
Albendazole sulphoxide (ABZSO), albendazole sulphone (ABZSO2), and albendazole (ABZ) stability determined in human saliva under different conditions.
Matrix | Condition | Concentration(µg/mL) | ABZSO | ABZSO2 | ABZ |
---|---|---|---|---|---|
%CV | |||||
Saliva | Freeze/thaw cycles (3x) | 0.05 | 8.93 | 6.86 | 7.33 |
0.5 | 12.2 | 11.5 | 12.1 | ||
2 | 5.17 | 5.06 | 10.2 | ||
4 °C, 45 days | 0.05 | 10.7 | 17.9 | 41.0 | |
0.5 | 10.3 | 15.1 | 31.4 | ||
2 | 4.88 | 10.2 | 14.5 | ||
− 20 °C,45 days | 0.05 | 15.3 | 16.2 | 23.2 | |
0.5 | 11.4 | 19.9 | 31.5 | ||
2 | 4.94 | 11.6 | 11.4 | ||
DBS | rt, 45 days | 0.2 | 9.09 | 17.5 | 12.5 |
0.6 | 16.5 | 9.27 | 11.2 | ||
2 | 16.9 | 10.9 | 18.8 |
rt: room temperature.