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. 2024 Feb 16;21(3):e00336. doi: 10.1016/j.neurot.2024.e00336

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© 2024 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 3 — Quantitative analysis of immunofluorescent staining of neuropathic pain markers on the injured side of dorsal root ganglion. BDNF (brain-derived neurotrophic factor), cyclooxygenase 2 (COX2), and c-Myc significant increase in signal intensity were induced after nerve injury in the control group compared to the uninjured nerve as the baseline. After UHF stimulation on Day 1, the signal intensity decreased and returned to increase on day five after electrical stimulation therapy. Similarly, substance P (SP), MEK, and c-Fos over injured DRG significantly increased signal intensity after nerve injury in the control group compared to the uninjured nerve as the baseline. After electrical stimulation therapy on Day 1, the signal intensity decreased and still reduced compared to the injured nerve of the control group on day five after UHF stimulation. (n = 4 per timepoint Data was presented with mean ± standard deviation, ∗ indicated p < 0.05; ∗∗ indicated p < 0.01, ∗∗∗ indicated p < 0.001, ∗∗∗∗ indicated p < 0.00001, and ns indicated no significant difference).