Table 3.
Predictive performance of PRS for breast cancer risk.
| Characteristics | Comparison | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | ||
| Overall (n = 6335) | |||||
| PRS subgroup | High versus low | 1.85 (1.25, 2.71) | 0.002 | 1.86 (1.25, 2.75) | 0.002 |
| Age at mammography | Years | 0.99 (0.96, 1.01) | 0.356 | 1.03 (0.99, 1.07) | 0.116 |
| Family history of BC | Yes versus no | 1.36 (0.72, 2.36) | 0.299 | 1.44 (0.76, 2.52) | 0.226 |
| Previous pregnancy | Yes versus no | 1.04 (0.61, 1.91) | 0.893 | 1.14 (0.65, 2.13) | 0.671 |
| Breast surgery history | Yes versus no | 1.53 (0.79, 2.69) | 0.172 | 1.68 (0.82, 3.21) | 0.134 |
| Benign breast disease | Yes versus no | 0.75 (0.48, 1.13) | 0.181 | 0.51 (0.31, 0.81) | 0.006 |
| Self-exam experience | Yes versus no | 1.02 (0.61, 1.61) | 0.940 | 1.43 (0.85, 2.33) | 0.163 |
| Breast symptoms | Yes versus no | 5.80 (3.73, 8.79) | < 0.001 | 7.03 (4.38, 11.1) | < 0.001 |
| Others cancer | Yes versus no | 0.47 (0.14, 1.12) | 0.139 | 0.42 (0.13, 1.04) | 0.099 |
| Age at menarche | Years | 0.90 (0.78, 1.04) | 0.194 | 0.90 (0.77, 1.04) | 0.173 |
| Menopause | Yes versus no | 0.61 (0.41, 0.92) | 0.015 | 0.48 (0.26, 0.88) | 0.018 |
| OC | Yes versus no | 1.59 (0.91, 2.61) | 0.083 | 1.59 (0.91, 2.65) | 0.087 |
| HRT | Yes versus no | 1.05 (0.58, 1.75) | 0.873 | 1.02 (0.56, 1.73) | 0.957 |
| Harrel’s C-index (95% CI) | 0.565 (0.520–0.611)a | 0.727 (0.677–0.777)b | |||
| No symptom (n = 5914) | |||||
| PRS subgroup | High versus low | 2.25 (1.43, 3.50) | < 0.001 | 2.23 (1.41, 3.48) | < 0.001 |
| Age at mammography | Years | 0.99 (0.96, 1.02) | 0.531 | 1.04 (1.0, 1.09) | 0.087 |
| Family history of BC | Yes versus no | 1.31 (0.61, 2.49) | 0.454 | 1.30 (0.60, 2.49) | 0.470 |
| Previous pregnancy | Yes versus no | 1.15 (0.61, 2.49) | 0.689 | 1.20 (0.61, 2.63) | 0.622 |
| Breast surgery history | Yes versus no | 1.31 (0.55, 2.68) | 0.495 | 1.81 (0.71, 4.03) | 0.170 |
| Benign breast disease | Yes versus no | 0.67 (0.39, 1.10) | 0.128 | 0.57 (0.31, 0.99) | 0.054 |
| Self-exam experience | Yes versus no | 1.43 (0.85, 2.33) | 0.159 | 1.43 (0.85, 2.34) | 0.163 |
| Others cancer | Yes versus no | 0.48 (0.12, 1.30) | 0.219 | 0.47 (0.11, 1.30) | 0.210 |
| Age at menarche | Years | 0.93 (0.78, 1.07) | 0.416 | 0.94 (0.78, 1.08) | 0.468 |
| Menopause | Yes versus no | 0.55 (0.35, 0.88) | 0.011 | 0.37 (0.18, 0.76) | 0.007 |
| OC | Yes versus no | 1.70 (0.89, 2.99) | 0.084 | 1.72 (0.90, 3.04) | 0.080 |
| HRT | Yes versus no | 0.76 (0.33, 1.48) | 0.457 | 0.75 (0.33, 1.48) | 0.446 |
| Harrel’s C-index (95% CI) | 0.589 (0.534–0.644)a | 0.682 (0.623–0.741)b | |||
Significant p-values are in bold.
BC breast cancer, OC oral contraceptive use, HRT hormone replacement therapy.
aHarrel’s C-index for PRS subgroup in univariate model.
bHarrel’s C-index for multivariate model with all retained variables.