Table 2.
Univariate and multivariate Cox-proportional hazards regression analysis of co-variates on survival
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | ||||
| < 70 years | 0.53 (0.41–0.69) | < 0.001 | 0.67 (0.49–0.91) | 0.010 |
| > 70 years | ||||
| Gender | ||||
| Male | 1.21 (0.98–1.50) | 0.73 | 1.01 (0.81–1.26) | 0.960 |
| Female | ||||
| WHO performance status | 1.48 (0.99–2.20) | 0.054 | 1.32 (0.88–1.98) | 0.187 |
| MGMT status | ||||
| Methylated < 10% | 0.69 (0.52–0.91) | 0.009 | 0.76 (0.57–1.01) | 0.054 |
| Methylated 10–25% | 0.58 (0.37–0.93) | 0.024 | 0.61 (0.38–0.97) | 0.036 |
| Methylated > 25% | 0.54 (0.37–0.80) | 0.002 | 0.58 (0.39–0.86) | 0.007 |
| Unmethylated | ||||
| Extent of resection | ||||
| > 95% resection | 0.69 (0.55–0.87) | < 0.001 | 0.71 (0.56–0.90) | 0.004 |
| < 95% resection | ||||
| DTI | 0.99 (0.78–1.25) | 0.912 | 0.89 (0.66–1.21) | 0.465 |
| 5-ALA | 0.93 (0.76–1.14) | 0.502 | 1.09 (0.84–1.43) | 0.508 |
| iUSS | 1.09 (0.89–1.35) | 0.406 | 1.04 (0.82–1.32) | 0.758 |
| Chemo–radiotherapy | ||||
| RT 60/30 + TMZ | 0.22 (0.15–0.32) | < 0.001 | 0.19 (0.13–0.29) | < 0.001 |
| RT 40/15 + TMZ | 0.33 (0.19–0.57) | < 0.001 | 0.23 (0.13–0.42) | < 0.001 |
| RT 60/30 alone | 0.65 (0.36–1.19) | 0.161 | 0.32 (0.17–0.59) | < 0.001 |
| RT 40/15 alone | 1.31 (0.77–2.22) | 0.325 | 0.63 (0.36–1.12) | 0.115 |
| RT 30/15 alone | 1.92 (0.67–5.48) | 0.226 | 1.13 (0.38–3.35) | 0.828 |
| No CRT | ||||
| Repeat resection | ||||
| 1 Resection | ||||
| 2 Resections | 0.37 (0.28–0.49) | < 0.001 | 0.41 (0.30–0.55) | < 0.001 |
| 3 Resections | 0.15 (0.09–0.25) | < 0.001 | 0.16 (0.09–0.28) | < 0.001 |