Fig. 2. High-resolution IgG antibody epitope mapping using ACE2 peptide microarray identified regions of targeted binding in individuals with severe COVID-19.

a Schematic of ACE2 protein over peptide regions with known domains and motifs highlighted. b Line graphs of median group z-scores of ACE2 autoantibody binding to individual ACE2 peptides. Epitopes of recurrent high binding were qualified as median z-scores of ≥1 to represent 1 standard deviation above the median. Seven regions qualified as high binding (grey; labeled peptide ID a–g). c Heatmap of z-scores for ACE2 epitope binding for individual samples, n = 20.