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. 2024 Feb 9;43(6):904–930. doi: 10.1038/s44318-024-00044-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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(A) Volcano plot of ubiquitylated proteins in SVEC4-10 cells treated for 3 h with 10 μΜ ABT-737, 10 μΜ S63845 and 30 μΜ Q-VD-OPh. The experiment performed with n = 4 independent repeats. Statistical analysis determining significance (coloured dots) was through using Student’s t test. Plot generated in RStudio. (B) Pie chart of ubiquitylated peptides categorised into mitochondrial compartments. Categorisation of peptides was performed using MitoCarta 3.0, UniProt and ProteinAtlas. (C) Cellular distribution of all hits from the isolated ubiquitin remnant-containing peptides. Categorisation using MitoCarta 3.0, UniProt and ProteinAtlas. (D) GO-term cellular compartment analysis of proteins with increased ubiquitylation after MOMP. Statistical analysis was performed with Fisher’s exact test with corrected with false discovery rate. Graphs shows the top ten most significant hits. Source data are available online for this figure.