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. 2024 Mar 8;6(2):fcae071. doi: 10.1093/braincomms/fcae071

Figure 5.

Figure 5

Protein expression is associated with characteristic findings in CADASIL patients. (A) Linear models with CXCL8/IL-8 as predictor and ePVS and WMH volume as outcomes. (B) Linear models with CCL2/MCP-1 as predictor and ePVS volume, BPF, MMSE score and TRAILB completion time as outcomes. (C) Overlap of proteins associated with specific neuropathological findings. Note that there was no protein associated with all three measures simultaneously. See Supplementary Table 3 for protein abbreviation list. BPF, brain parenchymal fraction; CCL2/MCP-1, C-C motif chemokine ligand 2/monocyte chemoattractant protein 1; CDRBox, Clinical Dementia Rating Sum-of-Boxes; CXCL8/IL-8, CXC motif chemokine ligand 8/interleukin-8; MMSE, Mini-Mental State Examination; Rey10 m, Rey–Osterrieth Complex Figure Test delayed recall at 10 min; RFU, relative fluorescent unit; TRAILB, Trail B Test completion time; WMH, white matter hyperintensity.