Table 1.
Summary of demographic, clinical and imaging characteristics
| CADASIL (n = 24) | Control (n = 24) | P-value | |
|---|---|---|---|
| Demographics | |||
| Age, (range) | 50.69 ± 12.45 (23–75) | 52.82 ± 11.26 (28–75) | 0.54 |
| Sex, n (%) female | 16 (67%) | 16 (67%) | 1.0 |
| Education in years | 14.70 ± 4.17 | 17.09 ± 2.13 | 0.02* |
| Cognitive measures | |||
| Clinical Dementia Rating (CDR) global score | 0.17 ± 0.24 | 0.02 ± 0.10 | 0.01* |
| CDR Sum-of-Boxes | 0.54 ± 0.83 | 0.15 ± 0.50 | 0.01* |
| Mini-Mental State Examination (MMSE) total score | 27.72 ± 2.49 | 29.52 ± 0.59 | 0.02* |
| Trail B Test Time (TRAILB) (sec) | 84.67 ± 65.72 | 47.88 ± 14.69 | |
| Rey–Osterrieth Complex Figure Test recall at 10 min (Rey10 m) | 12.24 ± 2.19 | 13.36 ± 2.08 | 0.09 |
| Imaging characteristics | |||
| Brain parenchymal fraction (BPF) | 0.77 ± 0.06 | 0.78 ± 0.03 | 0.54 |
| Total white matter hyperintensity (WMH) volume (mm3) | 12 723.27 ± 8334.02 | 1306.34 ± 721 | 0.0000007* |
| Enlarged perivascular spaces (ePVS) volume (mm3) | 547.75 ± 441.38 | 487.88 ± 747.55 | 0.73 |
Values are reported as mean ± standard deviation. Two-tailed Student’s t-tests or the non-parametric Wilcoxon rank sum was used for statistical comparison of continuous and nominal measures, and Chi-square tests were performed to compare group characteristics. *P-value < 0.05.