Table 2.

Unadjusted and adjusted linear regression model associations with standardized ePVS volume as main predictor and imaging and cognitive measures as outcomes

	Unadjusted models
	CADASIL (n = 24)		Control (n = 24)		All (n = 48)
	β (95% CI)	P-value	β (95% CI)	P-value	β (95% CI)	P-value
WMH volume (scaled)	0.57 (0.01 to 1.14)	0.05*	0.006 (−0.03 to 0.04)	0.70	0.19 (−0.10 to 0.48)	0.20
BPF	−0.03 (−0.06 to 0.005)	0.10	0.001 (−0.01 to 0.01)	0.80	−0.006 (−0.02 to 0.007)	0.38
CDRBox	0.49 (0.03 to 0.95)	0.04*	−0.03 (−0.20 to 0.15)	0.77	0.12 (−0.09 to 0.32)	0.26
MMSE	−1.38 (−3.21 to 0.46)	0.13	0.11 (−0.10 to 0.32)	0.28	−0.16 (−0.76 to 0.44)	0.59
TRAILB	31.16 (−9.55 to 71.88)	0.13	−12.06 (−37.71 to 13.59)	0.33	33.36 (6.93 to 59.78)	0.01*
Rey10 m	−0.14 (−1.55 to 1.27)	0.84	−0.04 (−0.84 to 0.76)	0.91	−0.14 (−0.82 to 0.54)	0.68

	Adjusted models for age, sex and education
WMH volume (scaled)	0.36 (−0.17 to 0.88)	0.17	0.002 (−0.03 to 0.04)	0.91	0.03 (−0.24 to 0.30)	0.80
BPF	−0.02 (−0.05 to 0.008)	0.14	0.004 (−0.006 to 0.01)	0.43	−0.003 (−0.01 to 0.009)	0.63
CDRBox	0.41 (0.04 to 0.77)	0.03*	−0.07 (−0.22 to 0.09)	0.37	0.09 (−0.09 to 0.28)	0.31
MMSE	−0.48 (−2.59 to 1.63)	0.63	0.07 (−0.17 to 0.31)	0.56	0.10 (−0.50 to 0.71)	0.73
TRAILB	20.1 (−14.66 to 54.85)	0.24	−19.72 (−40.11 to 0.68)	0.06	24.03 (−1.56 to 49.64)	0.06
Rey10 m	−0.13 (−1.73 to 1.47)	0.86	−0.008 (−0.92 to 0.90)	0.99	−0.06 (−0.81 to 0.70)	0.88

BPF, brain parenchymal fraction; CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy; CDRBox, Clinical Dementia Rating Sum-of-Boxes; MMSE, Mini-Mental State Examination; Rey10 m, Rey–Osterrieth Complex Figure Test delayed recall at 10 min; TRAILB, Trail B Test completion time; WMH, white matter hyperintensity. *P-value < 0.05.