Table 1.
Demographics and biomarker information.
| Young (N = 25) | CU− (N = 107) | CU+ (N = 32) | MCI+ (N = 42) | AD (N = 47) | MCI− (N = 19) | non-AD (N = 22) | |
|---|---|---|---|---|---|---|---|
| Female sex | 17 (68.0%) | 63 (58.9%) | 23 (71.9%) | 26 (61.9%) | 24 (51.1%) | 9 (47.4%) | 15 (68.2%) |
| Age, years | 22.6 (1.44) | 68.7 (9.03) | 73.1 (8.17) | 71.0 (5.73) | 66.7 (7.78) | 68.5 (11.0) | 63.1 (9.86) |
| Race | |||||||
| Asian | 11 (44.0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (2.1%) | 1 (5.3%) | 1 (4.5%) |
| Black or African American | 0 (0%) | 0 (0%) | 0 (0%) | 1 (2.4%) | 0 (0%) | 0 (0%) | 0 (0%) |
| White | 14 (56.0%) | 107 (100%) | 32 (100%) | 40 (95.2%) | 46 (97.9%) | 18 (94.7%) | 20 (90.9%) |
| Ethnicity | |||||||
| Hispanic or Latino | 0 (0%) | 0 (0%) | 1 (3.1%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (4.5%) |
| Not Hispanic or Latino | 25 (100%) | 107 (100%) | 31 (96.9%) | 42 (100%) | 47 (100%) | 19 (100%) | 21 (95.5%) |
| MMSE, score | 30.0 (0.20) | 29.1 (1.01) | 28.8 (1.24) | 28.0 (1.80) | 19.7 (6.74) | 27.9 (1.60) | 25.1 (6.23) |
| p-tau 217 ALZpath, pg/ml | 0.16 [0.11, 0.20] | 0.23 [0.16, 0.32] | 0.48 [0.30, 0.91] | 0.79 [0.53, 1.11] | 1.35 [0.97, 1.86] | 0.31 [0.19, 0.41] | 0.21 [0.16, 0.35] |
| p-tau 217+ Janssen, pg/ml | 0.04 [0.02, 0.04] | 0.04 [0.03, 0.05] | 0.08 [0.05, 0.11] | 0.13 [0.10, 0.18] | 0.23 [0.17, 0.35] | 0.05 [0.04, 0.07] | 0.05 [0.04, 0.07] |
| CSF p-tau 217, pg/ml | 6.69 [5.33, 7.80] | 10.4 [7.37, 16.1] | 28.2 [24.1, 50.1] | 45.6 [29.0, 77.7] | 67.8 [48.3, 102] | 11.4 [8.97, 17.4] | 9.62 [6.56, 11.1] |
| Composite [18F]AZD4694 SUVR | 1.17 [1.13, 1.21] | 1.27 [1.21, 1.35] | 2.01 [1.72, 2.27] | 2.37 [2.09, 2.59] | 2.43 [2.15, 2.68] | 1.3 [1.24, 1.35] | 1.23 [1.17, 1.36] |
| Med. Temp. [18F]MK6240 SUVR | 0.74 [0.69, 0.81] | 0.83 [0.74, 0.89] | 1.04 [0.83, 1.35] | 1.71 [0.95, 2.25] | 2.30 [1.80, 2.76] | 0.84 [0.73, 0.90] | 0.80 [0.71, 0.93] |
| Neocortical composite [18F]MK6240 SUVR | 0.84 [0.78, 0.90] | 0.81 [0.75, 0.85] | 0.84 [0.79, 0.94] | 1.05 [0.87, 1.66] | 2.80 [1.86, 3.32] | 0.79 [0.75, 0.88] | 0.78 [0.74, 0.90] |
| WMH | 2.72 [1.88, 3.36] | 3.83 [2.66, 6.17] | 5.83 [3.34, 8.02] | 5.35 [3.66, 9.84] | 6.63 [4.65, 9.94] | 7.00 [3.60, 11.6] | 5.74 [3.57, 7.27] |
Data are presented as count (%) or mean (Standard Deviation, SD), except for the fluid and imaging biomarkers which were given in median (IQR). No statistical difference was found in the proportion of sex types between groups (Chi-squared = 6.40, P = 0.37, S = 1.43). Age was statistically different between the groups, even when the Young group was not included in the model (ANOVA F = 4.80, P = 0.00032, S = 11.60; post hoc analysis, with Tukey HSD, showed that the CU+ (P = 0.00039, S > 13.32) and MCI+ (P = 0.0056, S = 7.48) groups are older than the non-AD group, whereas CU+ is older than the AD group (P = 0.013, S = 6.26)). The non-AD group comprises patients with clinical diagnoses such as Frontotemporal Dementia, Progressive Supranuclear Palsy, Alzheimer's Dementia Syndrome, and Mixed Dementia.