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. 2024 Mar 16;22:286. doi: 10.1186/s12967-024-05086-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — YAP overexpression exaggerates cartilage degeneration in post-traumatic OA rats. A Schematic diagram of animal experiment. B The body weight of rats. C IHC staining to show the YAP-positive cell in cartilage (scale bar: 100 μm). D The CT three-dimensional reconstruction images of rats (scale bar: 1 mm). E H&E staining and Safranin O/Fast green of the six groups (scale bar: 500 μm). F, G Immunohistochemistry staining to show the COL2A1-positive cell, MMP13-positive cell and P62-positive cell in cartilage of the six groups (scale bar: 100 μm). Data are shown as mean ± SD. *P < 0.05, **P < 0.01, *** P < 0.001