Table 1.
Baseline characteristics of patients with interstitial lung disease and lung cancer at lung cancer diagnosis
| Characteristic | Total (n = 163) |
IPF-LC (n = 92) |
Non-IPF-LC (n = 71) |
p Value |
|---|---|---|---|---|
| Type of ILD | ||||
| IPF | 92 (56.4) | 92 (100.0) | 0 (0.0) | |
| Unclassifiable | 54 (33.1) | 0 (0.0) | 54 (76.1) | |
| CTD-ILD | 0 (0.0) | 0 (0.0) | 14 (82.4) | |
| NSIP | 0 (0.0) | 0 (0.0) | 2 (11.8) | |
| Chronic HP | 0 (0.0) | 0 (0.0) | 1 (5.89) | |
| Age, years | 70.4 ± 7.3 | 70.5 ± 7.4 | 70.2 ± 7.2 | 0.827 |
| Male | 151 (92.6) | 85 (92.4) | 66 (93.0) | 0.899 |
| BMI, kg/m 2 | 24.4 ± 3.1 | 24.4 ± 2.8 | 24.4 ± 3.5 | 0.956 |
| Ever-smoker | 149 (91.4) | 84 (91.3) | 65 (91.5) | 0.827 |
| Pulmonary function test | ||||
|
FVC (predicted), % (n = 161) |
76.6 ± 16.8 | 76.5 ± 16.4 | 76.9 ± 17.5 | 0.884 |
|
FEV1 (predicted), % (n = 161) |
81.2 ± 15.8 | 80.9 ± 15.2 | 81.5 ± 16.7 | 0.812 |
|
TLC (predicted), % (n = 81) |
79.6 ± 13.4 | 79.3 ± 12.8 | 80.10 ± 14.47 | 0.800 |
|
DLco (predicted), % (n = 150) |
55.7 ± 17.6 | 54.5 ± 17.7 | 57.39 ± 17.45 | 0.319 |
| Laboratory data | ||||
|
KL-6 ≥ 1000 U/mL (n = 117) |
32 (27.4) | 20 (28.6) | 12 (25.5) | 0.718 |
| Type of LC | ||||
| NSCLC | 141 (86.5) | 81 (88.0) | 60 (84.5) | 0.512 |
| Adenocarcinoma | 74 (52.5) | 43 (53.1) | 31 (51.7) | 0.867 |
| Squamous cell carcinoma | 64 (45.4) | 35 (43.2) | 29 (48.3) | 0.546 |
| Othersa | 3 (2.1) | 3 (3.7) | 0 (0.0) | 0.261 |
| SCLC | 22 (13.5) | 11 (12.0) | 11 (15.5) | 0.512 |
Data are expressed as mean ± standard deviation for continuous variables and number (percentage) for categorical variables. ILD, interstitial lung disease; IPF, idiopathic progressive fibrosis; CTD, connective tissue disease; HP, hypersensitivity pneumonitis; NSIP, nonspecific interstitial pneumonia; BMI, body mass index; FVC, forced vital capacity; FEV1, forced expiratory volume in 1 s; TLC, total lung capacity; DLco, diffusing capacity for carbon monoxide; KL-6, Krebs von den Lungen-6; IS, immunosuppressants, LC; lung cancer, NSCLC; non-small cell lung cancer; SCLC, small cell lung cancer
a Other histological types include large cell carcinoma