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. 2024 Mar 16;23:56. doi: 10.1186/s12943-024-01952-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Avidity of CAR-T cells on tumor and normal cells. (A) Avidity of CAR-T cells on skrc-59 ccRCC tumor cells. The percentage of G250 (green), G36 (orange), G9 (pink), A716 (black), UNT (grey) binding to skrc-59 ccRCC tumor cells are shown in the plot (n = 4 per group). (B) Avidity of CAR-T cells on skrc-59 tumor cells at 1000 pN endpoint. The normalized percentage of G250 (green), G36 (orange), G9 (pink), A716 (black) binding to skrc-59 ccRCC tumor cells at 1000 pN are shown in the bar plot (the normalized percentage of binding is defined by minus the binding of UNT) (n = 4 per group). (C) Avidity of CAR-T cells on MMNK-1 cholangiocytes. The percentage of G250 (green), G36 (orange), G9 (pink), A716 (black), UNT (grey) binding to MMNK-1 cholangiocytes are shown in the plot (n = 4 per group). (D) Avidity of CAR-T cells on MMNK-1 cholangiocytes at 1000 pN endpoint. The normalized percentage of G250 (green), G36 (orange), G9 (pink), A716 (black) binding to MMNK-1 cholangiocytes at 1000 pN are shown in the bar plot (the normalized percentage of binding is defined by minus the binding of UNT) (n = 4 per group). All data with error bars are presented as mean ± SD. P values are defined by unpaired two-tailed t-tests (∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; and ∗∗∗∗p < 0.0001)