Table 7.
Diagnostic accuracy using Bayesian latent class analysis: BLCM model I
| Model I | Subgroups | Median (95% credible interval) (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Parasitological technique | Prevalence | Sensitivity | Specificity | Positive predictive value | Negative predictive value | ||||||
| Direct blood examination (10 µl)/thick blood smear (50 µl) | Global | 9.7 | 6.2–13.7 | 78.9 | 65.3–90.3 | 100.0 | 99.3–100.0 | 99.1 | 87.2–100.0 | 93.0 | 87.3–97.7 |
| Age group | |||||||||||
| 15–64 years | 8.8 | 5.1–13.0 | 76.3 | 62.4–90.0 | 99.9 | 99.2–100.0 | 99.1 | 86.7–100.0 | 93.0 | 87.3–97.7 | |
| Other age groupsb | |||||||||||
| Gender | |||||||||||
| Male | 11.3 | 5.5–17.7 | 73.3 | 56.2–87.3 | 99.9 | 98.6–100.0 | 99.1 | 86.8–100.0 | 93.0 | 87.3–97.6 | |
| Female | 8.4 | 4.6–12.6 | 75.7 | 61.0–88.9 | 99.9 | 99.1–100.0 | 99.1 | 86.9–100.0 | 93.0 | 87.2–97.6 | |
| Symptomatology | |||||||||||
| Symptomsb | |||||||||||
| Loiasis-related symptoms | 9.1 | 4.6–14.6 | 72.3 | 56.4–87.5 | 99.9 | 98.9–100.0 | 99.1 | 86.5–100.0 | 93.0 | 87.2–97.6 | |
| No symptoms | 10.2 | 5.7–15.6 | 76.1 | 61.2–89.3 | 99.9 | 98.9–100.0 | 99.1 | 87.3–100.0 | 93.0 | 87.2–97.7 | |
| Eosinophilia | |||||||||||
| Normal | 4.5 | 1.5–8.2 | 68.7 | 50.2–85.3 | 99.9 | 99.9–100.0 | 99.1 | 86.9–100.0 | 93.0 | 87.1–97.6 | |
| Hypereosinophiliab | |||||||||||
| Leukoconcentration(5 ml)a | Global | 9.7 | 6.2–13.7 | 99.9 | 97.8–100.0 | 91.4 | 88.6–94.1 | 74.1 | 66.0–81.7 | 99.9 | 98.8–100.0 |
| Age groups | |||||||||||
| 15–64 years | 8.8 | 5.1–13.0 | 99.8 | 97.7–100.0 | 90.7 | 87.6–93.5 | 74.0 | 66.0–82.1 | 98.8 | 98.8–100.0 | |
| Other age groupsb | |||||||||||
| Gender | |||||||||||
| Male | 11.3 | 5.5–17.7 | 99.8 | 97.5–100.0 | 88.6 | 84.9–92.3 | 74.1 | 65.4–81.7 | 99.9 | 98.8–100.0 | |
| Female | 8.4 | 4.6–12.6 | 99.8 | 97.5–100.0 | 90.8 | 87.6–93.6 | 74.1 | 66.0–81.9 | 99.9 | 98.8–100.0 | |
| Symptomatology | |||||||||||
| Symptomsb | |||||||||||
| Loiasis-related symptoms | 9.1 | 4.6–14.6 | 99.8 | 97.5–100.0 | 89.1 | 85.4–92.4 | 74.1 | 65.9–81.9 | 99.9 | 98.8–100.0 | |
| No symptoms | 10.2 | 5.7–15.6 | 99.8 | 97.4–100.0 | 90.1 | 86.7–93.3 | 74.1 | 66.1–82.2 | 99.9 | 98.8–100.0 | |
| Eosinophilia | |||||||||||
| Normal | 4.5 | 1.5–8.2 | 99.8 | 97.2–100.0 | 90.2 | 86.9–93.4 | 74.1 | 65.8–81.7 | 99.9 | 98.8–100.0 | |
| Hypereosinophiliab | |||||||||||
aImperfect reference test
bModel did not converge for this particular population subgroup