Table 1.
Baseline patient demographics and clinical characteristics
| RAS mutation (n = 302) | KRASG12 mutation (n = 214) | KRASG12C mutation (n = 24) | Non-KRASG12RAS mutation (n = 88) | RAS wild-type (n = 148) | RAS wild-type or a non-KRASG12RAS mutation (n = 236) | |
|---|---|---|---|---|---|---|
| Median age, years | 63 | 64 | 60.5 | 62 | 62 | 62 |
| Male, n (%) | 153 (50.7) | 112 (52.3) | 12 (50.0) | 41 (46.6) | 80 (54.1) | 121 (51.3) |
| Race or ethnic group, n (%) | ||||||
| White | 266 (88.1) | 186 (86.9) | 21 (87.5) | 80 (90.9) | 133 (89.9) | 213 (90.3) |
| Black | 6 (2.0) | 6 (2.8) | 0 | 0 | 1 (0.7) | 1 (0.4) |
| Asian | 0 | 0 | 0 | 0 | 1 (0.7) | 1 (0.4) |
| Other | 11 (3.6) | 8 (3.7) | 3 (12.5) | 3 (3.4) | 2 (1.4) | 5 (2.1) |
| Missing | 19 (6.3) | 14 (6.5) | 0 | 5 (5.7) | 11 (7.4) | 16 (6.8) |
| Geographic region, n (%) | ||||||
| North America | 8 (2.7) | 6 (2.8) | 1 (4.2) | 2 (2.3) | 6 (4.1) | 8 (3.4) |
| European Union | 199 (65.9) | 140 (65.4) | 17 (70.8) | 59 (67.0) | 98 (66.2) | 157 (66.5) |
| Rest of the world | 95 (31.5) | 68 (31.8) | 6 (25.0) | 27 (30.7) | 44 (29.7) | 71 (30.1) |
| Primary diagnosis, n (%) | ||||||
| Colon cancer | 220 (72.9) | 162 (75.7) | 18 (75.0) | 58 (65.9) | 108 (73.0) | 166 (70.3) |
| Rectal cancer | 82 (27.1) | 52 (24.3) | 6 (25.0) | 30 (34.1) | 40 (27.0) | 70 (29.7) |
| Location of primary tumor, n (%) | ||||||
| Right side | 91 (30.1) | 65 (30.4) | 7 (29.2) | 26 (29.6) | 35 (23.6) | 61 (25.8) |
| Left side | 211 (69.9) | 149 (69.6) | 17 (70.8) | 62 (70.4) | 113 (76.4) | 175 (74.2) |
| Number of metastatic sites, n (%) | ||||||
| 1/2 | 182 (60.3) | 132 (61.7) | 14 (58.3) | 50 (56.8) | 90 (60.8) | 140 (59.3) |
| ≥3 | 120 (39.7) | 82 (38.3) | 10 (41.7) | 38 (43.2) | 58 (39.2) | 96 (40.7) |
| ECOG performance status, n (%) | ||||||
| 0 | 129 (42.7) | 93 (43.5) | 13 (54.2) | 36 (40.9) | 74 (50.0) | 110 (46.6) |
| 1 | 173 (57.3) | 121 (56.5) | 11 (45.8) | 52 (59.1) | 73 (49.3) | 125 (53.0) |
| 2 | 0 | 0 | 0 | 0 | 1 (0.7) | 1 (0.4) |
ECOG, Eastern Cooperative Oncology Group.