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In vitro ubiquitination of CK1α by E3 CRL4CRBN.A, time course. B, dropout. CK1α was subject to ubiquitination reaction containing E3 CRL4CRBN and lenalidomide (1 μM) with details described in the Experimental procedures section. Both high- and low-contrast fluorescent scans are shown. Species∗ most likely represents autophosphorylated form of CK1α. Percentage of CK1α consumed is indicated. CK1α, casein kinase 1α; CRBN, cereblon; CRL, Cullin–RING E3 Ub ligase.
