Table 5.

Association of risk indicators of chronic kidney disease with number of APOL1 risk variants, compared to 0 variants, adjusted for age, sex, body mass index, diabetes, hypertension, Townsend deprivation index, and genetic principal components 1–4.

Genotype	n (total)	uACR > 3 mg/mmol or eGFR < 60 mL/min/1.73m2		uACR > 3 mg/mmol		eGFR < 60 mL/min/1.73m2
		Odds ratio (95% CI)	p	Odds ratio (95% CI)	p	Odds ratio (95% CI)	p
0 variants	2853	1.0 (ref)		1.0 (ref)		1.0 (ref)
1 variant	3492	1.1 (0.9–1.3)	0.52	1.1 (0.9–1.4)	0.18	0.9 (0.7–1.3)	0.69
2 variants	1117	1.4 (1.1–1.8)	0.002	1.5 (1.2–2.0)	0.001	1.4 (1.0–2.0)	0.05

Genotypes with p values < 0.05 are shown in bold. Carriage of two APOL1 risk variants was associated with having chronic kidney disease risk indicators, consistent with previous studies.² The numbers and percentages are shown in Supplementary Table S7.