Table 1.
Characteristics of study participants by population group and inclusion in analysis after filtering
| First ANC users | Children 2–10 years | |||||
|---|---|---|---|---|---|---|
| All | Passed filtering | Filtered out | All | Passed filtering | Filtered out | |
| Total number N (%) | 378 (100) | 289 (76.5) | 89 (23.5) | 180 (100) | 93 (51.7) | 87 (48.3) |
| Age median years (IQR) | 21 (18;27) | 21 (18;27) | 22 (19;29) | 4.0 (3.0;6.3) | 4.6 (3.0;6.8) | 4.0 (3.0;6.0) |
| Parasite density GM parasite/µL (GSD) | 86.6 (16.9) | 191 (12.4) | 6.6 (9.0) | 41.1 (18.7) | 154 (12.8) | 7.1 (11.7) |
| Year | ||||||
| 2015–2016, n (%) | 0 | 0 | 0 | 93 (100) | 60 (64.5) | 33 (35.5) |
| 2017, n (%) | 210 (100) | 166 (79.0) | 44 (21.0) | 21 (100) | 4 (19.0) | 17 (81.0) |
| 2018–2019, n (%) | 168 (100) | 123 (73.2) | 45 (26.8) | 66 (100) | 29 (43.9) | 37 (56.1) |
| Area | ||||||
| Magude, n (%) | 155 (100) | 120 (77.4) | 35 (22.6) | 101 (100) | 47 (46.5) | 54 (53.5) |
| Manhiça, n (%) | 87 (100) | 64 (73.6) | 23 (26.4) | 71 (100) | 42 (59.2) | 29 (40.8) |
| Ilha Josina, n (%) | 136 (100) | 105 (77.2) | 31 (22.8) | 8 (100) | 4 (50.0) | 4 (50.0) |
| Season | ||||||
| Dry, n (%) | 233 (100) | 182 (78.1) | 51 (21.9) | 180 (100) | 93 (51.7) | 87 (48.3) |
| Rainy, n (%) | 145 (100) | 107 (73.8) | 38 (26.2) | 0 (0) | 0 (0) | 0 (0) |
| HIV | ||||||
| Negative, n (%) | 291 (100) | 221 (75.9) | 70 (24.1) | NA | NA | NA |
| Positive, n (%) | 87 (100) | 68 (78.2) | 19 (21.8) | NA | NA | NA |
| Gravidity | ||||||
| Primigravid, n (%) | 143 (100) | 117 (81.9) | 26 (18.2) | NA | NA | NA |
| Multigravid, n (%) | 235 (100) | 172 (73.2) | 63 (26.8) | NA | NA | NA |
| Sequencing coverage | ||||||
| Reads/sample, GM (GSD) | 6.8 × 104 (27.2) | 3.2 × 105 (4.0) | 470 (15.5) | 8.5 × 103 (100.0) | 4.8 × 105 (5.3) | 115 (8.7) |
| N loci* covered/sample, median (IQR) | 221 (173;224) | 223 (209;225) | 75 (25;128) | 170 (41;214) | 213 (208;224) | 40 (13.5;81) |
All available samples were sequenced. Those that did not pass the filtering criteria were excluded, while the remaining samples were included in the analysis. Population groups are (1) pregnant women attending their first antenatal care (ANC) visit, and (2) children aged 2-10 years sampled in population-representative household surveys.
N number, IQR interquartile range, GM geometric mean, GSD geometric standard deviation, NA not applicable. *On average, each locus was covered by 1.4 million reads and 462 samples.