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. 2024 Mar 16;43:84. doi: 10.1186/s13046-024-03001-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Extravascular platelet clusters in AT-3 tumors from chronic and severe thrombocytopenic mice. (A) Representative image of immunostaining for platelet factor 4 (PF4) in mammary AT-3 tumors from mice with chronic severe thrombocytopenia (c-mpl−/− mice treated with R300 antibody). Note the abundance of platelet clusters at the tumor periphery. (B) Immunostaining for platelets (PF4, VWF, GPIX) showing the presence of extravascular platelet clusters in AT-3 tumors from mice with chronic severe thrombocytopenia. White boxes show higher magnification views of the squared areas