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. 2024 Feb 24;76(2):109–121. doi: 10.1007/s00251-024-01333-z

Table 2.

Alleles with differences in the non-coding (5′ UTR/introns/3′ UTR) sequences compared to the reference allele

HLA allele Compared to Differences in non-coding regions Comment
A*03:182 A*03:01:01:01 I6 C2605T Not unique for A*03
B*18:34 B*18:01:01:01 I3 T1127C, I5 A2180G, 3' UTR T3014C, C3358T, C3472T, C3609T No differences with B*18:01:01:02
B*53:06 B*53:01:01:01 10 differencesa Possible recombination
C*03:04:19 C*03:04:01:01 I3 G1030A Possible recombination
C*16:201 C*16:01:01:01 5’ UTR G-415A Unique for C*16
DQA1*01:06 DQA1*01:01:01:01 Many differencesb Possible recombination
DQA1*04:04 DQA1*04:01:01:01 3205 Ins A homopolymer
DQB1*03:114 DQB1*03:01:01:01 I1 C744T, I2 G3363A Not unique for DQB1*03
DQB1*06:03:11 DQB1*06:01:01:01 > 300 differences No differences with DQB1*06:03:01:01
DQB1*06:73 DQB1*06:01:01:01 > 300 differences No differences with DQB1*06:02:01:01
DQB1*06:286 DQB1*06:01:01:01 > 300 differences No differences with DQB1*06:02:01:01
DPA1*01:03:14 DPA1*01:03:01:01 I1 G1723A, I1 C3318G, I2 G4149C Not unique for DPA1*01

I intron, E exon, UTR untranslated region, number indicates the position of the genomic sequence according to the IPD-IMGT/HLA database

aSee Table 3 for details

bSee Table 4 for details