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. 2024 Feb 24;76(2):109–121. doi: 10.1007/s00251-024-01333-z

Table 5.

HLA class I alleles extended with 5′ and 3′ UTR sequences with the EMBL-ENA accession numbers, IPD-IMGT/HLA submission numbers and the number of non-coding nucleotides for 5′ and 3′ UTR added to the database

HLA allele Compared to EMBL-ENA accession number IPD-IMGT/HLA submission number Non-coding nucleotides added 5′ UTR Non-coding nucleotides added 3′ UTR Differences in extended sequence
A*02:01:01:48 A*02:01:01:01 OX421037 HWS10065285 0 185
A*29:95 A*29:01:01:01 OX421046 HWS10065287 150 231
B*07:02:01:32 B*07:02:01:01 OX421012 HWS10065289 248 1022
B*07:06:01:01 B*07:02:01:01 OX463247 HWS10065965 0 659 T3358C, C3698G
B*07:436 B*07:02:01:01 OX421031 HWS10065291 0 659 C3053T, C3129T, G3341A, T3358C, T3472C, T3576C, A3636G
B*08:09 B*08:01:01:01 OX421023 HWS10065293 0 660
B*14:81 B*14:02:01:01# OX421015 HWS10065295 248 986
B*15:03:01:01 B*15:01:01:01 OX421050 HWS10065297 284 1022 C2902T, C3174T, T3524C, G3542A, C3622T, C3681A
B*15:07:01:02 B*15:01:01:01 OX421032 HWS10065299 16 766
B*15:13:01 B*15:01:01:01 OX421014 HWS10065301 16 1011 T3485C, T3524C, C3622T, C3681A
B*15:37 B*15:01:01:01 OX421035 HWS10065303 57 777 T3524C, G3542A, C3622T, C3681A
B*18:01:01:18 B*18:01:01:01 OX421036 HWS10065305 0 659 C3358T
B*18:18:01:02 B*18:01:01:01 OX421052 HWS10065309 0 983 T3014C, C3358T, C3472T, C3576T, C3609T, C3668A
B*18:144 B*18:01:01:01 OX421022 HWS10065307 0 670 C3358T, C3472T, C3576T, C3609T, C3668A
B*27:06:01:01 B*27:04:01# OX421057 HWS10065311 0 659 T3509A, G3531A
B*35:05:01:01 B*35:01:01:02# OX421028 HWS10065313 0 129 C3604T, C3611T
B*35:30:01:01 B*35:01:01:02# OX421047 HWS10065315 0 984 A3188C, T3255G, A3259G, G3317A, T3362C, G3363A, T3377G, G3381T, T3389C, G3416C, T3439C, T3461C, C3604T, C3611T
B*40:23 B*40:01:02:01# OX421021 HWS10065537 0 659
B*40:27:01 B*40:02:01:01 OX421054 HWS10065539 0 661
B*41:02:01:05 B*42:01:01:01#a OX421040 HWS10065541 0 1005
B*44:02:01:14 B*44:02:01:01 OX421033 HWS10065543 0 659
B*44:03:01:14 B*44:02:01:01 OX421055 HWS10065545 0 660 T3412G, T3472C, T3506A, G3523A
B*44:04 B*44:02:01:01 OX421048 HWS10065547 16 659 T3412G, T3472C, T3506A, G3523A
B*49:01:01:02 B*49:01:01:01 OX421056 HWS10065551 0 659
B*51:01:01:14 B*51:01:01:01 OX421020 HWS10065553 131 811 T3525C, G3702C
B*51:01:01:25 B*51:01:01:01 OX421034 HWS10065555 27 679 G3702C
B*51:01:01:31 B*51:01:01:01 OX421045 HWS10065557 0 699 C3439T, C3461T, C3613T, G3702C
B*56:01:01:03 B*56:01:01:15# OX463248 HWS10065969 0 659
B*81:01:01:04 B*81:01:01:01b OX421058 HWS10065559 248 1022
C*02:02:02:06 C*02:02:02:01 OX421019 HWS10065561 0 235
C*02:02:02:14 C*02:02:02:01 OX421044 HWS10065569 192 638
C*02:02:02:20 C*02:02:02:01 OX421016 HWS10065571 212 638
C*02:02:02:27 C*02:02:02:01 OX421027 HWS10065573 431 797
C*02:06:01 C*02:02:02:01 OX421038 HWS10065575 201 652
C*03:02:02:02 C*03:02:02:01#c OX421051 HWS10065577 212 589 A3196G, G3200C, C3305T, G3325T, A3372C, 3387_3388insG, C3423T, G3429A, C3439T, G3498A
C*03:03:01:22 C*03:02:02:01#c OX421018 HWS10065581 431 801 A3196G, G3200C, C3305T, G3325T, A3372C, 3387_3388insG, C3423T, G3429A, C3439T, G3498A
C*03:04:02:01 C*03:02:02:01#c OX421042 HWS10065583 0 278 A3196G, G3200C, C3305T, G3325T, A3372C, 3387_3388insG, C3423T, G3429A, C3439T, G3498A
C*04:01:01:19 C*04:01:01:06# OX421049 HWS10065587 111 620
C*04:01:01:38 C*04:01:01:06# OX421029 HWS10065589 431 820
C*06:02:01:21 C*06:02:01:01 OX421024 HWS10065591 431 819 G3033C
C*07:02:01:44 C*07:01:01:01 OX421030 HWS10065593 435 819 G3000A, T3001C
C*07:46 C*07:01:01:01 OX421053 HWS10065595 204 658
C*12:03:01:28 C*12:02:02:01 OX421039 HWS10065597 431 794 C3638T, G3664A
C*12:143 C*12:02:02:01 OX421025 HWS10065599 0 291 C3638T, G3664A
C*12:167 C*12:02:02:01 OX421013 HWS10065601 373 794 G3664A
C*15:06:01:01 C*15:02:01:01 OX421026 HWS10065603 0 291
C*17:01:01:05 C*17:01:01:02 OX421041 HWS10065607 0 286

The extended sequences were compared with the first allele of the same allele group, and the differences are depicted in the last column. A hash symbol behind the reference allele indicates that this is not the first allele of the allele group for which the genomic sequence is known, because the first allele is missing part of the 3′ UTR region

aThis B*41:02:01:05 allele had to be compared with another allele group, because there was no B*41 in the database with known sequence up to position 3698

bThe last 131 bp of this B*81:01:01:04 allele could not be compared to any B*81 allele, because it was unknown for all B*81 alleles

cThe allele C*03:02:02:01 was the first allele of the C*03 allele group of which the full-length sequence is known, but this allele together with 03:544 and 03:614 showed these 10 differences with the alleles studied, all other C*03 alleles showed sequences identical to the 3 studied alleles