Table 2.
Univariate and Multivariate COX regression analysis of prognostic factors associated with OS in training cohort
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Gender (female vs. male) | 0.990 (0.643–1.525) | 0.964 | – | – |
| Age (years) (≥ 60 vs. < 60) | 1.348 (0.887–2.049) | 0.162 | – | – |
| Tumor size (cm) (< 4 vs. ≥ 4) | 0.711 (0.470–1.075) | 0.106 | – | – |
| Differentiation status (well + moderate vs. poor and undifferentiated) | 0.738 (0.462–1.178) | 0.203 | – | – |
| Lauren type (diffuse type vs. intestinal type) | 1.303 (0.850–1.996) | 0.224 | – | – |
| Depth of invasion (T1 + T2 vs. T3 + T4) | 0.426 (0.261–0.695) | 0.001 | 0.751 (0.445–1.268) | 0.285 |
| Lymph node metastasis (N0 vs. N1 + N2 + N3) | 0.238 (0.119–0.477) | < 0.0001 | 0.961 (0.355–2.599) | 0.937 |
| TNM stage (I + II vs. III) | 0.186 (0.107–0.325) | < 0.0001 | 0.211 (0.095–0.467) | < 0.001 |
| CPNE3 (high vs. low) | 1.751 (1.138–2.693) | 0.011 | 1.555 (1.003–2.412) | 0.049 |