Table 3.
Univariate and multivariate COX regression analysis of prognostic factors associated with OS in validation cohort
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Gender (female vs. male) | 0.776 (0.518–1.162) | 0.218 | – | – |
| Age (years) (≥ 60 vs. < 60) | 0.969 (0.657–1.429) | 0.874 | – | – |
| Tumor size (cm) (< 4 vs. ≥ 4) | 0.889 (0.601–1.314) | 0.555 | – | – |
| Differentiation status (well + moderate vs. poor and undifferentiated) | 0.750 (0.501–1.123) | 0.162 | – | – |
| Lauren type (diffuse type vs. intestinal type) | 0.788 (0.534–1.162) | 0.230 | – | – |
| Depth of invasion (T1 + T2 vs. T3 + T4) | 0.571 (0.373–0.875) | 0.010 | 0.967 (0.596–1.571) | 0.893 |
| Lymph node metastasis (N0 vs. N1 + N2 + N3) | 0.346 (0.192–0.621) | < 0.001 | 0.958 (0.376–2.440) | 0.929 |
| TNM stage (I + II vs. III) | 0.321 (0.195–0.528) | < 0.0001 | 0.361 (0.158–0.826) | 0.016 |
| CPNE3 (high vs. low) | 1.810 (1.204–2.720) | 0.004 | 1.540 (1.006–2.358) | 0.047 |