Table 4.
Univariate and Multivariate COX regression analysis of prognostic factors associated with OS in training + validation cohort
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Gender (female vs. male) | 0.873 (0.650–1.173) | 0.368 | – | – |
| Age (years) (≥ 60 vs. < 60) | 1.135 (0.854–1.508) | 0.383 | – | – |
| Tumor size (cm) (< 4 vs. ≥ 4) | 0.798 (0.601–1.060) | 0.119 | – | – |
| Differentiation status (well + moderate vs. poor and undifferentiated) | 0.757 (0.559–1.025) | 0.072 | – | – |
| Lauren type (diffuse type vs. intestinal type) | 0.995 (0.748–1.324) | 0.973 | – | – |
| Depth of invasion (T1 + T2 vs. T3 + T4) | 0.503 (0.365–0.692) | < 0.0001 | 0.887 (0.625–1.260) | 0.503 |
| Lymph node metastasis (N0 vs. N1 + N2 + N3) | 0.292 (0.186–0.456) | < 0.0001 | 0.973 (0.495–1.914) | 0.938 |
| TNM stage (I + II vs. III) | 0.247 (0.171–0.359) | < 0.0001 | 0.277 (0.157–0.489) | < 0.0001 |
| CPNE3 (high vs. low) | 1.783 (1.326–2.397) | < 0.001 | 1.525 (1.124–2.071) | 0.007 |