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The expanding CRISPR/Cas system-based toolkits. A Base editing technology by fusing nCas9 (D10A) with adenosine deaminase or cytidine deaminase for targeted point mutation. B Prime editing technology by fusing nCas9 (H840A) with reverse transcriptase and pegRNA for precise genome editing without a double-strand DNA break. C Using CRISPR/Cas9 system with sgRNA library for genome-wide mutations. D CRISPR/Cas9 system can induce chromosome rearrangement by targeted double-strand breaks
