TABLE 1.

Antiproliferative activities of tested compounds.

Entry	Compound	IC50 (µM)
		SKOV3	BT20	A549	HCT116	MRC5
1	COL	11.58 ± 2.33	21.98 ± 1.30	2.39 ± 1.40	9.32 ± 0.2	5.72 ± 2.1
2	1E	2.92 ± 0.28	7.07 ± 1.28	>50	>50	>50
3	1Z	>50	>50	>50	>50	>50
4	2E	41.58 ± 2.46	15.83 ± 2.90	>50	>50	>50
5	2Z	>50	17.28 ± 3.44	>50	>50	>50
6	3E	>50	ND	>50	>50	>50
7	3Z	>50	ND	>50	>50	>50
8	4E	>50	ND	>50	>50	>50
9	4Z	>50	ND	>50	>50	>50
10	5E	3.84 ± 1.56	8.31 ± 1.26	18.85 ± 1.20	>50	>50
11	5Z	29.81 ± 2.09	19.92 ± 3.42	>50	>50	>50
12	6E	12.44 ± 1.18	27.79 ± 5.31	>50	>50	>50
13	6Z	31.33 ± 4.42	12.61 ± 1.76	>50	>50	>50
14	7E	2.62 ± 0.53	10.02 ± 2.17	29.34 ± 1.10	>50	>50
15	7Z	>50	>50	>50	>50	>50
16	8E	>50	ND	>50	>50	>50
17	8Z	>50	ND	>50	>50	>50
18	9E	8.08 ± 2.08	4.98 ± 2.77	21.38 ± 0.83	>50	>50
19	9Z	>50	20.24 ± 3.78	>50	>50	>50
20	10E	>50	ND	>50	>50	>50
21	10Z	>50	ND	>50	>50	>50
22	11E	28.85 ± 2.15	21.67 ± 0.67	>50	>50	>50
23	11Z	38.29 ± 2.31	>50	>50	>50	>50
24	12E	7.35 ± 1.42	7.0 ± 1.96	9.89 ± 0.25	16.10 ± 1.20	14.39 ± 0.86
25	12Z	11.93 ± 1.88	11.94 ± 1.10	>50	>50	>50

ND, not determined. COL, colchicine. Bold values are numbers of synthesized compounds.