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. 2024 Mar 4;4:1258184. doi: 10.3389/fragi.2023.1258184

FIGURE 2.

FIGURE 2

DHM inhibits DNA methylation in primary human keratinocytes. (A) Principal component analysis based on 101,067 differentially methylated probes in the complete dataset obtained with primary human keratinocytes from different donors (n = 13). (B) DHM-dependent hypomethylation in primary human keratinocytes. Box plots indicate the distribution of beta values of the 101,067 differentially methylated probes in the complete dataset. *p = 1.4 × 10−33, t-test. (C) DHM-dependent hypomethylation in epigenomic substructures. *Padj < 6.7 × 10−4, t-test.