Table 1.
Baseline characteristics of training and validation cohorts.
| Variable | development cohort (n=729) |
validation cohort (n=313) | p-value |
|---|---|---|---|
| Male sex, n (%) | 395 (54.2) | 176 (56.2) | 0.543 |
| Hypertension, n (%) | 360 (49.4) | 144 (45.9) | 0.346 |
| Diabetes, n (%) | 108 (14.8) | 42 (13.4) | 0.502 |
| Hyperlipidemia, n (%) | 132 (18.1) | 60 (19.2) | 0.685 |
| Smoking history, n (%) | 262 (35.9) | 121 (38.7) | 0.404 |
| Alcohol consumption, n (%) | 257 (35.3) | 115 (36.7) | 0.646 |
| Age (year) | 57 ± 10 | 56 ± 10 | 0.416 |
| Heart rate (bpm) | 76 ± 12 | 77 ± 12 | 0.600 |
| SBP (mmHg) | 131 ± 17 | 130 ± 17 | 0.196 |
| DBP (mmHg) | 76 ± 11 | 76 ± 11 | 0.787 |
| Height (cm) | 166.7 ± 8.1 | 167.0 ± 8.7 | 0.530 |
| Weight (kg) | 73.1 ± 13.5 | 73.4 ± 13.7 | 0.672 |
| BMI (kg/m2) | 26.2 ± 3.7 | 26.2 ± 3.6 | 0.921 |
| LVEDD (mm) | 44.65 ± 3.89 | 44.38 ± 3.72 | 0.307 |
| LVESD (mm) | 29.86 ± 3.17 | 29.47 ± 2.91 | 0.066 |
| EF (%) | 61.59 ± 4.83 | 62.10 ± 4.72 | 0.119 |
| IVSd (mm) | 10.66 ± 1.18 | 10.61 ± 1.17 | 0.544 |
| LA-ap (mm) | 34.32 ± 3.95 | 34.31 ± 4.01 | 0.957 |
| Mitral valve E peak velocity (m/s) | 0.65 ± 0.16 | 0.66 ± 0.16 | 0.607 |
| Mitral valve A peak velocity (m/s) | 0.77 ± 0.17 | 0.76 ± 0.18 | 0.467 |
| AV-v (m/s) | 1.31 ± 0.24 | 1.29 ± 0.25 | 0.231 |
| Mitral valve E/A ratio | 0.88 ± 0.28 | 0.90 ± 0.30 | 0.212 |
| LVM (g) | 236.3 ± 48.5 | 232.4 ± 50.3 | 0.239 |
| Urea (mmol/l) | 5.31 ± 1.41 | 5.26 ± 1.38 | 0.620 |
| Creatinine (µmol/l) | 73.0 ± 14.8 | 72.8 ± 15.5 | 0.896 |
| Uric acid (µmol/l) | 331.9 ± 88.9 | 335.8 ± 91.6 | 0.519 |
| Potassium (mmol/l) | 3.73 ± 0.33 | 3.72 ± 0.35 | 0.942 |
| TC (mmol/l) | 4.10 ± 0.93 | 4.18 ± 1.00 | 0.081 |
| HDL-C (mmol/l) | 1.15 ± 0.31 | 1.15 ± 0.31 | 0.905 |
| LDL-C (mmol/l) | 2.51 ± 0.82 | 2.61 ± 0.8 | 0.058 |
| HBG (g/l) | 139.2 ± 15.1 | 139.3 ± 15.1 | 0.957 |
| WBC (10^9/L) | 6.32 ± 1.60 | 6.24 ± 1.62 | 0.445 |
| Neutrophil ratio | 0.58 ± 0.90 | 0.57 ± 0.09 | 0.071 |
| Lymphocyte ratio | 0.32 ± 0.09 | 0.33 ± 0.08 | 0.067 |
| Platelet count (10^9/L) | 221.5 ± 55.8 | 219.0 ± 52.7 | 0.498 |
| Diameters of coronary arteries | |||
| LCA (mm) | 4.44 ± 0.85 | 4.44 ± 0.90 | 0.968 |
| LAD (mm) | 3.47 ± 0.67 | 3.45 ± 0.66 | 0.646 |
| LCX (mm) | 3.11 ± 0.66 | 3.07 ± 0.75 | 0.459 |
| RAD (mm) | 3.42 ± 0.72 | 3.38 ± 0.72 | 0.317 |
| CTFC | |||
| LAD (frames) | 36 ± 16 | 36 ± 17 | 0.870 |
| LCX (frames) | 29 ± 14 | 30 ± 15 | 0.239 |
| RCA (frames) | 30 ± 15 | 31 ± 17 | 0.283 |
| ALT (U/l, Median [IQR]) | 18.1 (13.5-26.2) | 19.4 (13.0-28.5) | 0.974 |
| AST (U/l, Median [IQR]) | 16.9 (14.2-20.5) | 16.6 (14.1-22.0) | 0.427 |
| cTnT (ng/ml, Median [IQR]) | 0.006 (0.004-0.008) |
0.006 (0.004-0.008) |
0.930 |
| Glucose (mmol/l, Median [IQR]) | 5.31 (4.82-6.02) | 5.35 (4.78-5.93) | 0.436 |
| CK (U/L, Median [IQR]) | 76.2 (58.9-105.8) | 76.2 (55.8-102.6) | 0.409 |
| Myoglobin (U/L, Median [IQR]) | 24.0 (21.0-30.3) | 23.4 (21.0-30.7) | 0.642 |
| CK-MB (ng/ml, Median [IQR]) | 1.18 (0.86-1.62) | 1.16 (0.82-1.63) | 0.493 |
| NT-proBNP (pg/ml, Median [IQR]) | 46.4 (24.4-92.7) | 46.9 (24.3-90.1) | 0.989 |
| TG (mmol/l, Median [IQR]) | 1.40 (1.05-1.95) | 1.41 (1.06-1.95) | 0.740 |
| NLR (Median [IQR]) | 1.84 (1.40-2.46) | 1.78 (1.31-2.29) | 0.089 |
| SII (Median [IQR]) | 387 (292-530) | 382 (270-517) | 0.130 |