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. 2024 Mar 4;14:1275930. doi: 10.3389/fonc.2024.1275930

Table 1.

Favored surgical techniques for surgical management of periocular cutaneous malignancies.

Favored surgical techniques Basal cell carcinoma Squamous cell carcinoma Sebaceous cell carcinoma Melanoma Merkel cell carcinoma
Pre-operative map biopsy Yes
Wide local excision Yes (1-2cm margin)
Excision with frozen section margin control Yes (especially for nodular varieties)
Staged excision with permanent fixation for margin control Yes
Mohs surgery or other PDEMA techniques Yes Yes Yes Yes (needs “slow Mohs” technique with use of permanent fixation) Yes
Sentinel lymph node biopsy Yes (tumor diameter >10 mm or recurrence) Yes (Breslow thickness >1.0 mm) Yes

Note that choice of surgical technique depends on tumor and patient factors, and more detailed algorithms may be found via the National Comprehensive Cancer Network (NCCN) website at www.nccn.org. Patients should be counseled on risks of progression or toxicity prior to planned surgery. Complex cases should be considered with a multidisciplinary approach of oculofacial surgeons, radiation and medical oncologists in accordance with patient’s preferences and goals.

PDEMA, peripheral and deep en face margin assessment