TABLE 2.

Müller glia (MG) genes associated with inherited retinal degeneration ^a .

OMIM#	Gene	Protein	Cell type	Function	Phenotype b
600308	AQP4	Aquaporin 4	MG (Li et al., 2002)	Modulating water homeostasis in the retina	Inherited retinal dystrophy (Lassiale et al., 2016)
613858	PRSS56	Serine protease 56	MG (Paylakhi et al., 2018)	Modulating ocular axial growth	Microphthalmia, isolated 6
600342	RGR	Retinal G protein-coupled receptor	Retinal pigment epithelium (RPE); MG (Jiang et al., 1993)	Converting all-trans retinal to 11-cis retinal	Retinitis pigmentosa 44
180090	RLBP1	Retinaldehyde binding protein 1	RPE and MG (Maw et al., 1997)	Visual cycle	Bothnia retinal dystrophy; Fundus albipunctatus; Newfoundland rod-cone dystrophy; Retinitis punctata albescenes
604210	CRB1	Crumbs cell polarity complex component 1	Photoreceptor; MG (Pellissier et al., 2014)	Cellular polarity	Leber congenital amaurosis 8; Retinitis pigmentosa 12; Pigmented paravenous chorioretinal atrophy

^a Unless otherwise specified, this table summarizes information of MG-associated genes in OMIM, Online Mendelian Inheritance in Man (https://www.omim.org/).

^b We note that multiple genes in inherited retinal degeneration are associated with syndromic disorders with multi-organ pathology. Only phenotypes associated with the retina are listed in the table.