Table 2.
Brain regions with significant differences in amplitude of low frequency fluctuations between patients with Crohn’s disease and healthy controls.
| Regions | BA | Hem | MNI peak coordinate | Voxel size | T value | ||
|---|---|---|---|---|---|---|---|
| X | Y | Z | |||||
| CD-A > HCs | - | - | - | - | - | - | - |
| Frontal Pole | 10 | L | −15 | 69 | 6 | 594 | 4.621 |
| Supramarginal Gyrus | 48 | R | 59 | −23 | 26 | 56 | 4.877 |
| Angular Gyrus | 22 | L | −63 | −57 | 21 | 45 | 4.432 |
| CD-A < HCs | - | - | - | - | - | - | - |
| Cingulate Gyrus | 24 | R | 6 | 24 | 24 | 103 | −4.387 |
| Intracalcarine Cortex | 17 | R | 15 | −69 | 12 | 69 | −4.278 |
| CD-R > HCs | - | - | - | - | - | - | - |
| Frontal Pole | 9 | L | 12 | 54 | 37 | 188 | 3.842 |
| Supramarginal Gyrus | 2 | R | 66 | −24 | 30 | 56 | 3.682 |
| CD-R < HCs | - | - | - | - | - | - | - |
| Cingulate Gyrus | 24 | R | 3 | 7 | 33 | 165 | −4.279 |
| Parahippocampal Gyrus | 28 | R | 24 | −6 | −39 | 40 | −4.077 |
| CD-A < CD-R | - | - | - | - | - | - | - |
| Lingual Gyrus | 19 | R | 21 | −63 | −12 | 52 | −3.203 |
| Precuneous Cortex | 19 | R | 3 | −81 | 42 | 32 | −3.025 |
| Occipital Fusiform Gyrus | 19 | L | −33 | −69 | −18 | 27 | −3.260 |
The results employed gender, age intracranial volume and FD Jenkinson as covariates. The statistical threshold was set at voxel p < 0.001, cluster p < 0.01, and two-tailed (GRF correction). CD-A refers to Crohn’s disease patients in activity. CD-A refers to patients with Crohn’s disease in activity. CD-R refers to patients with Crohn’s disease in remission. HCs refer to Healthy controls. GMV, gray matter volume; Hem, hemisphere; BA, Brodmann area; L, left; R, right.