Figure 8.

Associations of RSV and RV-specific IgG levels with personal determinants and seasons of blood sampling in children (EGEA1, n=531) and adults (EGEA2, n=1241). Multivariable mixed linear regression models were used to estimate beta and corresponding 95% CIs for virus-specific (RSV/RV) antibody levels associated with personal determinants and the seasons of blood sampling. Error bars represent 95% CIs. EGEA, Epidemiological study on the Genetics and Environment of Asthma; RSV, respiratory syncytial virus; RV, rhinovirus; BMI, body mass index; Jan-Mar, January-March; Apr-Jun, April-June; Jul-Sep, July-September; Oct-Dec, October-December. Beta were estimated from linear mixed regression models for repeated data (random effect on family) with IgG level as dependent variable and age (continuous), sex, BMI (continuous), season of blood sampling (4 seasons), tobacco (passive in EGEA1, active in EGEA2), allergic sensitization and ever-asthma as predictors. *Age and BMI were standardized (divided by their Standard deviation (SD)), thus beta are reported for 1 SD increased. SD of age in EGEA1: 2.85 years; SD of age in EGEA2: 16.7 years; SD of BMI in EGEA1: 2.91 kg/m²; SD of BMI in EGEA2: 4.25 kg/m².