FIGURE 6.

Minocycline ameliorated the neuropsychiatric symptoms and neurodegeneration in MRL/lpr mice. (A, B) Representative images and quantification of IBA‐1⁺ microglia in the hippocampi of the indicated mice (n = 5). Scale bars as indicated. (C, D) Representative images and quantification of synapses by Golgi staining in hippocampal sections (n = 5). Scale bars as indicated. (E–G) Frequency of entries and time spent with the head in the open arms in the EPM test (n = 7). Total time in the maze: 6 min. The data are presented as the mean ± SEM. *p < 0.05; by t‐test (B, D, F, G). EPM, elevated‐plus maze; mino, minocycline.