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. 2024 Mar 7;10(6):e27427. doi: 10.1016/j.heliyon.2024.e27427

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© 2024 The Authors

This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Fig. 1 — The inhibition of mitochondrial oxidative phosphorylation has been observed in bladder cancer tissue. (A) The gene expression of three pairs of bladder cancer and adjacent tissue was analyzed using the Human Targets of Mitochondrial Oxidative Phosphorylation Related Gene qPCR Array. In comparison to adjacent tissues, a majority of genes exhibited down-regulation in all three bladder cancer tissues. (B) A Venn plot was generated to illustrate the overlap between down-regulated and up-regulated genes. The mRNA expressions of COX6A2, GADD45B, EDN1 and UQCRH were found to be concurrently down-regulated in all three cancer tissues.