Fig. 2.

The expression of GADD45B is significantly reduced in bladder cancer compared to the normal control group (A) The mRNA expression levels of COX6A2, GADD45B, EDN1 and UQCRH were compared between bladder tumor samples and normal samples. This comparison was conducted using the TCGA and GTEx datasets and analyzed through the utilization of GEPIA. (B) The mRNA expression level of GADD45B was examined across various cancer types using TCGA data. This analysis was performed using UALCAN. (C) The mRNA expression levels of bladder cancer tissues were investigated in paired samples obtained from the TCGA dataset. (D) The Human Protein Atlas database was utilized to obtain representative images depicting the immunohistochemistry staining intensities of GADD45B in both normal bladder tissue and bladder tumor. (E) The quantification of GADD45B mRNA expression was performed using qRT-PCR in both normal bladder tissues and cancer samples.