Fig. 3.

Effect of DIO on colonic A. muciniphila abundance (A) and MUC1, MUC2 (B) expressions as well as PIK3R3 (C) and ZO-1 (D) contents in mice with DSS-induced colitis. The values are presented as means of 6 mice ± SEM. One-way ANOVA was used for statistical analysis, followed by Tukey's post hoc test. *^{, #, ‡} Significantly different from normal, DSS-induced colitis and DSS + DIO 100 mg/kg groups at p < 0.05, respectively. DSS: dextran sulfate sodium; SSZ: sulfasalazine; DIO: diosmin; A. muciniphila: Akkermansia muciniphila; MUC1: mucin 1; MUC2: mucin 2; PIK3R3: Phosphoinositide-3-kinase regulatory subunit 3; ZO-1: zonula occlude.