Table 3.

Genes involved in nitrogen metabolism pathways in K. aerogenes between the DM1 and DM2 groups.

Involved metabolic pathways	Gene ID	Gene name	Function description	log2 (Fold change)
Nitrate assimilation	FPV33_RS05380	norV	Anaerobic nitric oxide reductase flavorubredoxin	9.73
	FPV33_RS05390	norR	Nitric oxide reductase transcriptional regulator NorR	2.12
	FPV33_RS14925	narI	Respiratory nitrate reductase subunit gamma	2.95
	FPV33_RS13560	FNR	Fumarate/nitrate reduction transcriptional regulator Fnr	1.32
	FPV33_RS11865	narG	Nitrate reductase subunit alpha	−1.27
	FPV33_RS11870	NarK	NarK family nitrate/nitrite MFS transporter	−1.44
	FPV33_RS14945	NarK	NarK family nitrate/nitrite MFS transporter	1.50
	FPV33_RS14980	ntrB	Nitrate ABC transporter permease	−1.11
Arginine metabolism	FPV33_RS18075	tatE	Twin-arginine translocase subunit TatE	−1.52
	FPV33_RS07020	argT	Lysine/arginine/ornithine ABC transporter substrate-binding protein ArgT	−1.87
	FPV33_RS16875	artQ	Arginine ABC transporter permease ArtQ	1.50
	FPV33_RS16870	artJ	Arginine ABC transporter substrate-binding protein	1.01
	FPV33_RS16880	artM	Arginine ABC transporter permease ArtM	1.24
	FPV33_RS02445	argR	Transcriptional regulator ArgR	2.14
	FPV33_RS23940	argH	Argininosuccinate lyase	1.08
Glutamate metabolism	FPV33_RS24240	glnA	Glutamate--ammonia ligase	−5.30
	FPV33_RS15685	putA	Trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	−1.45
	FPV33_RS02550	gltB	Glutamate synthase large subunit	−1.43
	FPV33_RS05525	gshA	Glutamate--cysteine ligase	1.74
	FPV33_RS10040	astD	Succinylglutamate-semialdehyde dehydrogenase	−1.37
	FPV33_RS19730	proB	Glutamate 5-kinase	1.22
	FPV33_RS10200	trpD	Bifunctional anthranilate synthase glutamate amidotransferase component TrpG/anthranilate phosphoribosyltransferase TrpD	−1.08
	FPV33_RS19735	proA	Glutamate-5-semialdehyde dehydrogenase	1.01
	FPV33_RS00465	gltS	Sodium/glutamate symporter	−1.14
	FPV33_RS09905	gapA	Glyceraldehyde-3-phosphate dehydrogenase	2.84
	FPV33_RS06275	fdx	ISC system 2Fe-2S type ferredoxin	1.75
	FPV33_RS03960	ndoA	Non-heme iron oxygenase ferredoxin subunit	−2.69
Ammonia assimilation	FPV33_RS06645	GAT1	Type 1 glutamine amidotransferase	2.31
	FPV33_RS17190	glnH	Glutamine ABC transporter substrate-binding protein GlnH	−3.20
	FPV33_RS06915	prmB	50S ribosomal protein L3 N(5)-glutamine methyltransferase	2.31
	FPV33_RS05015	pyrG	CTP synthase (glutamine hydrolyzing)	1.48
	FPV33_RS17865	glnS	Glutamine--tRNA ligase	1.48
	FPV33_RS17195	glnP	Glutamine ABC transporter permease GlnP	−1.83
	FPV33_RS17200	glnQ	Glutamine ABC transporter ATP-binding protein GlnQ	−1.72
	FPV33_RS02860	GATase1	Type 1 glutamine amidotransferase	−1.42
	FPV33_RS21860	FmdA_AmdA	Acetamidase/formamidase family protein	−1.63
	FPV33_RS14025	arcC	Carbamate kinase	−1.36
	novel0138	Ca1	Carbonic anhydrase	2.99
	FPV33_RS22225	CA	Carbonic anhydrase	−1.29