Table 2.
Diagnostic applications of mRNA. Disease biomarker changes reported with respect to controls.
| Indication | Biological Matrix | mRNA Biomarker | Source | |
|---|---|---|---|---|
| Cancer | Colorectal Cancer | Human Serum | ↑ Metadherin | 44 |
| Neurological diseases | Parkinson's Disease | Human Blood | ↑ IFIT1 ↑ IFIT2 ↑ IFIT3 ↑ IFI6 ↑ IRF7 ↓POLR3B ↓ CAMK4 ↓ OWAR6 ↓ LINC00861 ↓ AC083843.1 |
67 |
| Parkinson's Disease | MPTP-induced PD mouse peripheral blood | ↓ Vcp | 68 | |
| MPTP-induced PD mouse primary heterogenous brain tissues | ||||
| Human Peripheral Blood | ||||
| Autism Spectrum Disorder | Human Peripheral Blood | ↓ SOD2 ↓ ERRα ↓ RORA ↓ GPER |
74 | |
| Autism Spectrum Disorder | Human Peripheral Blood | ↓ OPRM1 ↓ PRKG1 ↓ HTR1E ↑ SCN9A ↑ DRD4 ↑ OPRL1 ↑ TACR1 |
76 | |
| Obstetric indications | Low Fertility | Primary Bovine Ovarian tissue | (Luteal phase) ↑ 161 mRNAs ↓ 296 mRNAs |
152 |
| (Follicular phase) ↑ 253 mRNAs ↓ 222 mRNAs | ||||