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Crystal structure of the S protein (PDB id 6VXX) (A) and its receptor-binding domain (RBD) (B). S protein is shown in ribbon representation colored in blue and green for S1 and S2 chains, respectively. (C) The interactions between RBD and the S-protein have been shown with S1 represented as sticks (PDB ID: 6VW1).99 RBD is presented as a solvent-accessible surface colored by interpolated charge: red–negative, blue–positive, gray–neutral.
