Figure 17.

(A) The epitopes of the E2-targeting antibodies. The proteins are shown in cartoon representation with the epitope amino acid side chains displayed as sticks (PDB id: 6MEI).¹⁵⁷ (B) The intermolecular interactions between AP33 and its epitope are shown in two ways: on the left, the epitope is represented as a blue ribbon with the interacting amino acid residues as sticks. On the right, the antibody is the solvent accessible surface colored according to interpolated charge (red–negative, blue–positive, gray–neutral), with the interacting residues of E2 displayed as blue sticks. Interactions are shown as dashed lines with the same color scheme shown in Figure 1 (PDB id: 4GAG).¹⁵³