Figure 19.

Glycoprotein GP in the complex with the Niemann-Pick C1 receptor (A) (PDB id: 5F1B)¹⁹⁵ and closeup showing intermolecular interactions (B). The glycoprotein GP in the complex with the IT0227 antibody (C), with a closeup of the interactions shown in (D) (PDB id: 6S8D).¹⁹⁶ The proteins are shown in ribbon representation colored by chain with magenta for GP-2, navy for GP-1, cyan for NPC1, red for the light chain of IT0227, and green for the heavy chain of IT01227. Interacting residues are shown as sticks colored by atom type, and the color of the carbon atoms matches that of the ribbon of the same chain. Interactions are shown as dashed lines with the same color scheme shown in Figure 1.