Table 2. Antibodies Targeting HCV Entry, Their Epitopes, and the Reported IC50.
name | target | epitope | IC50 |
---|---|---|---|
AR3A172,173 | E2 | L427, N428, C429, N430, D431, T439, F442, Y443, W529, E531 | 0.5 nM < 0.002 μM |
HC84.26.5D171 | W437, F442, Y443, K446 | 0.0013–0.0082 μMa | |
AP33153,174 | 412–423 aa (QLINTNGSWHIN) | 0.013–0.69 μMa | |
K21175 | CD81 | LEL | 56 ± 11 ng/mL |
JS81175 | LEL | 144 ± 43 ng/mL | |
mAb151176 | SRBI | Not determined | 0.5 nM |
7A5177 | CLDN1 | M152 (second extracellular loop) | 0.23 μg/mL |
Depending on the HCV variant.