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. 2024 Feb 23;67(5):3205–3231. doi: 10.1021/acs.jmedchem.3c01543

Table 2. Antibodies Targeting HCV Entry, Their Epitopes, and the Reported IC50.

name target epitope IC50
AR3A172,173 E2 L427, N428, C429, N430, D431, T439, F442, Y443, W529, E531 0.5 nM < 0.002 μM
HC84.26.5D171   W437, F442, Y443, K446 0.0013–0.0082 μMa
AP33153,174   412–423 aa (QLINTNGSWHIN) 0.013–0.69 μMa
K21175 CD81 LEL 56 ± 11 ng/mL
JS81175   LEL 144 ± 43 ng/mL
mAb151176 SRBI Not determined 0.5 nM
7A5177 CLDN1 M152 (second extracellular loop) 0.23 μg/mL
a

Depending on the HCV variant.