Streibelt 2009.

Methods	RCT conducted in Germany
Participants	Patients referred to rehabilitation centre from work insurance provider, limited work ability due to chronic musculoskeletal disorder. 222 patients randomised, 16.7% female, average age 45.8 years, mean duration of pain not reported
Interventions	MBR (FCEMR): 3 weeks inpatient program, 3‐4 hours treatment/day. Physical therapy, exercises, massage, education, relaxation. Focus on work‐specific skills and functional capacity with operant behavioural approach. Coping skills training Physical (MR, Control): 3 weeks inpatient program, 3‐4 hours treatment/day. Physical therapy, exercises, massage, education, relaxation
Outcomes	Disability (PDI), Work (weeks off‐work, % return to work) Follow‐ups: LT (1 year)
Notes	Subgroup analyses: Mid‐intensity intervention, Low baseline symptom intensity (<60% of maximum scale score)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	pg.4 Study design. "A computer‐generated randomization list was created by a statistician"
Allocation concealment (selection bias)	Low risk	pg.4 Study design. "Randomized allocation of the patients in either the treatment or the control group was done by an external institute"
Blinding of participants	High risk	Not possible
Blinding of clinicians	High risk	Not possible
Blinding of outcome assessment (detection bias) All outcomes	High risk	Not possible; patient reported outcome
Incomplete outcome data (attrition bias) All outcomes	High risk	pg.7 Sample. >50% dropout rate
Intention to treat analysis	Low risk	pg.6 Analysis. "Cases were analysed as intended to treat"
Selective reporting (reporting bias)	Unclear risk	No protocol
Comparability of groups at baseline	High risk	Baseline characteristics. Groups comparable on relevant demographic and clinical variables
Compliance	Unclear risk	Not stated
Cointerventions	Unclear risk	Not stated
Timing of assessment	Low risk	Fig 1. 1 year follow‐up