Figure 1. Left part: Schematic drawing of a horizontal section of the hypothalamus in which the Foxb1-neurons of the parvafox and of the PMd are located (modified after Alvarez-Bolado et al., 2000).
Their chemogenetic (DREADD) stimulation leads to an increase in breaths / minutes. Right part: dorsolateral PAG (dlPAG), seen in a cross-section of the midbrain. Axon terminals of parvafoxFoxb1 and PMdFoxb1 converge in the rostral part of the dlPAG. Optogenetic activation of these terminals lead to immobility and bradycardia.