Table 1. MIC (μg/mL) and IC₅₀ (μg/mL ± S.D.) Values for Blasticidin S (1), P10 (2), and Derivatives 15–22.

	MIC and IC50(μg/mL)
Organism	1	2	15	16	17	18	19	20	21	22
S. aureus ΔNorA	>256	64–128	128	128	64–128	128	64–128	64	256	128
	140 ± 8.7	14.0 ± 0.3	21.1 ± 0.4	19.6 ± 1.8	15.8 ± 1.1	18.3 ± 1.4	16.2 ± 0.9	15.2 ± 2.1	35.5 ± 2.5	19.3 ± 0.2
S. aureus	>256	32	32	32	16–32	64	32	16	64	16
	33.2 ± 0.8	4.7 ± 1.0	5.9 ± 1.2	5.3 ± 1.5	3.9 ± 0.1	7.0 ± 1.5	3.6 ± 0.3	2.5 ± 0.2	8.1 ± 0.7	3.8 ± 0.2
MRSA	256	32	32–64	32	16–32	32	16–32	32	32–64	8–16
	59.7 ± 7.8	7.0 ± 1.0	13.3 ± 3.3	14.9 ± 1.6	7.6 ± 0.8	12.8 ± 1.9	6.9 ± 1.2	7.2 ± 2.3	11.8 ± 0.2	4.0 ± 0.3
E. faecalis	32–64	16–32	16–32	16–32	16–32	16–32a	16–32	16–32	32	8
	26.3 ± 13	5.1 ± 4.3	13.2 ± 3.6	9.6 ± 4.0	9.3 ± 1.7	17.0	7.6 ± 1.5	11.1 ± 4.1	22.3 ± 4.0	6.1 ± 2.6
VRE	256	64	32	64	64	64–128	64	64	128	32
	58.0 ± 9.4	15.0 ± 8.6	13.5 ± 3.6	20.2 ± 8.1	16.8 ± 3.1	27.7 ± 11	21.1 ± 4.8	22.1 ± 12	15.3 ± 3.3	11.1 ± 0.8
K. pneumoniae	128	32	64	256	128–256	256	128	128	64	256
	42.3 ± 3.5	7.6 ± 1.3	26.4 ± 4.1	60.1 ± 6.2	44.9 ± 3.2	60.1 ± 4.7	40.4 ± 6.2	30.7 ± 5.3	19.7 ± 0.5	36.9 ± 4.7
P.aeruginosa	256	64	64–128	64–128	64	64–128	64	64	128	64
	61.0 ± 6.0	14.6 ± 1.5	20.2 ± 3.4	21.8 ± 2.7	19.3 ± 1.6	18.8 ± 2.6	16.1 ± 0.9	20.2 ± 1.3	34.1 ± 0.3	16.5 ± 2.1
A. baumannii	>256	16	64	128	>256	256	128	128	64–128	>256
	104 ± 25	4.5 ± 0.4	18.3 ± 5.3	35.7 ± 11	39.3 ± 1.9	46.4 ± 7.0	21.1 ± 3.9	24.3 ± 3.2	21.2 ± 0.6	183 ± 19

^aResult is based on one biological replicate (n = 2); standard deviation was not determined.