Table 2. CC50 (μg/mL) and SI (CC50/IC50) Values for Blasticidin S (1), P10 (2), and Derivatives 15–22.
| 1 | 2 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | |
|---|---|---|---|---|---|---|---|---|---|---|
| CC50(μg/mL) for human cells | ||||||||||
| MRC-5 (lung fibroblast)a | 20.1 | 5.9 | 52.8 | 137 | 61.1 | 63.9 | 33.1 | 65.9 | 58.1 | 58.4 |
| Selectivity index (CC50/IC50)for bacteria | ||||||||||
| S. aureus ΔNorA | 0.1 | 0.4 | 2.5 | 7.0 | 3.9 | 3.5 | 2.0 | 4.3 | 1.6 | 3.0 |
| S. aureus | 0.6 | 1.3 | 8.9 | 26 | 16 | 9.1 | 9.2 | 26 | 7.1 | 15 |
| MRSA | 0.3 | 0.8 | 4.0 | 9.2 | 8.1 | 5.0 | 4.8 | 9.1 | 4.9 | 15 |
| E. faecalis | 0.8 | 1.2 | 4.0 | 14 | 6.6 | 3.7b | 4.4 | 5.9 | 2.6 | 9.6 |
| VRE | 0.3 | 0.4 | 3.9 | 6.8 | 3.6 | 2.3 | 1.6 | 3.0 | 3.8 | 5.2 |
| K. pneumoniae | 0.5 | 0.8 | 2.0 | 2.3 | 1.4 | 1.1 | 0.8 | 2.2 | 3.0 | 1.6 |
| P. aeruginosa | 0.3 | 0.4 | 2.6 | 6.3 | 3.2 | 3.4 | 2.1 | 3.3 | 1.7 | 3.5 |
| A. baumannii | 0.2 | 1.3 | 2.9 | 3.8 | 1.6 | 1.4 | 1.6 | 2.7 | 2.7 | 0.3 |
a
Results are based on one biological replicate (n = 3); standard deviation was not determined, but results are representative of multiple trials.
b
Result is based on one biological replicate.