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. 2024 Jan 11;12:RP87607. doi: 10.7554/eLife.87607

Figure 13. Genes with isoform expression alterations played key roles in segregating cells between the hepatocellular carcinoma (HCC) and benign liver samples.

Figure 13.

(A) The role of isoform expressions in segregating cells between the HCC and benign liver when the standard deviation was ≥0.5. Left panel: Venn diagram between gene expressions and isoform expressions with standard deviations ≥ 0.5. Middle panel: Uniform Manifold Approximation and Projection (UMAP) clustering with genes not overlapping with isoforms. Right panel: UMAP clustering with genes overlapping with isoforms. (B) The role of isoform expressions in segregating cells between the HCC and benign liver when the standard deviation was ≥0.8. Left panel: Venn diagram between gene expressions and isoform expressions with standard deviations ≥ 0.8. Middle panel: UMAP clustering with genes not overlapping with isoforms. Right panel: UMAP clustering with genes overlapping with isoforms. Blowup panel: UMAP clustering with genes overlapping with isoforms in three subsampling trials. (C) The role of isoform expression in segregating cells between the HCC and benign liver when the standard deviation ≥ 1.0. Left panel: Venn diagram between gene expressions and isoform expressions with standard deviations ≥ 1.0. Middle panel: UMAP clustering with genes not overlapping with isoforms. Right panel: UMAP clustering with genes overlapping with isoforms. (D) The role of isoform expression in segregating cells between the HCC and benign liver when the standard deviation was ≥1.4. Left panel: Venn diagram between gene expressions and isoform expressions with a standard deviation ≥ 1.4. Middle panel: UMAP clustering with genes not overlapping with isoforms. Right panel: UMAP clustering with genes overlapping with isoforms.